LATE INHERITED NEUROSYPHILIS

Chronic or Late Lyme Neuroborreliosis: Analysis of Evidence Compared to Chronic or Late Neurosyphilis

Whether spirochetes persist in affected host tissues and cause the late/chronic manifestations of neurosyphilis was the subject of long-lasting debate. Detection of Treponema pallidum in the brains of patients with general paresis established a direct link between persisting infection and tertiary manifestations of neurosyphilis. Today, the same question is in the center of debate with respect ...

Early- and late-onset inherited erythromelalgia: genotype-phenotype correlation.

Inherited erythromelalgia (IEM), an autosomal dominant disorder characterized by severe burning pain in response to mild warmth, has been shown to be caused by gain-of-function mutations of sodium channel Na(v)1.7 which is preferentially expressed within dorsal root ganglion (DRG) and sympathetic ganglion neurons. Almost all physiologically characterized cases of IEM have been associated with o...

Late Neurosyphilis and Tertiary Syphilis in Guangdong Province, China: Results from a Cross-sectional Study

Due to challenges in diagnosis and the need for complex laboratory tests, misdiagnosis of neurosyphilis and tertiary syphilis is common in China. We validated the diagnosis and examined the treatment of late neurosyphilis and tertiary syphilis in Guangdong Province, China. A cross-sectional study was conducted to collect data from late neurosyphilis and tertiary syphilis cases reported between ...

The treatment of neurosyphilis.

The Silence of Neurosyphilis

Introduction Syphilis is a sexually transmitted infection. The infectious organism is a spirochete bacterium called Treponema pallidum subspecies pallidum. This organism also may transmit vertically inutero from mother to fetus resulting in congenital syphilis. The following is a case report of tertiary syphilis in the form of tabes dorsalis. This case is of interest due to the rarity of late n...